Publications

Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides

M. Garcia-Marquez, M. Thelen, Eugen Bauer, L. Maas, K. Wennhold, J. Lehmann, Diandra Keller, Miloš Nikolić, Julie George, Thomas Zander, W. Schröder, P. Müller, Ali M Yazbeck, Christiane J. Bruns, Roman Thomas, Birgit Gathof, A. Quaas, M. Peifer, Axel M. Hillmer, M. von Bergwelt-Baildon, H. Schlößer

Journal for ImmunoTherapy of Cancer, 2024

Tertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation.

J. Lehmann, M. Thelen, Christoph Kreer, S. Schran, M. Garcia-Marquez, Igor Cisic, Klara Siepmann, Elena M Hagen, H. Eckel, P. Lohneis, Stephan Kruger, Stefan Boeck, Steffen Ormanns, Martina Rudelius, Jens Werner, Felix Popp, Florian Klein, Michael von Bergwelt-Baildon, Christiane J. Bruns, A. Quaas, K. Wennhold, Hans A Schlößer

Cancer immunology research, 2024

Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells

M. Thelen, D. Keller, J. Lehmann, K. Wennhold, Hendrik T. Weitz, E. Bauer, B. Gathof, M. Brüggemann, M. Kotrová, A. Quaas, Christoph A Mallmann, S. Chon, A. Hillmer, C. Bruns, M. V. von Bergwelt-Baildon, M. Garcia-Marquez, H. Schlößer

Journal for ImmunoTherapy of Cancer, 2022

Post-transplant malignancies show reduced T-cell abundance and tertiary lymphoid structures as correlates of impaired cancer immunosurveillance.

R. Datta, S. Schran, O. Persa, C. Aguilar, M. Thelen, J. Lehmann, M. Garcia-Marquez, K. Wennhold, E. Preugszat, Peter Zentis, M. V. von Bergwelt-Baildon, A. Quaas, C. Bruns, C. Kurschat, C. Mauch, H. Löser, D. Stippel, H. Schlößer

Clinical Cancer Research, 2022

Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

M. Thelen, K. Wennhold, J. Lehmann, M. Garcia-Marquez, Sebastian Klein, Elena Kochen, P. Lohneis, A. Lechner, S. Wagener-Ryczek, P. Plum, Oscar Velázquez Camacho, D. Pfister, F. Dörr, M. Heldwein, K. Hekmat, D. Beutner, J. Klussmann, F. Thangarajah, D. Ratiu, W. Malter, S. Merkelbach-Bruse, C. Bruns, A. Quaas, M. V. von Bergwelt-Baildon, H. Schlößer

npj Precision Oncology, 2021

CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

K. Wennhold, M. Thelen, J. Lehmann, S. Schran, E. Preugszat, M. Garcia-Marquez, A. Lechner, A. Shimabukuro-Vornhagen, M. Ercanoglu, F. Klein, F. Thangarajah, S. Eidt, H. Löser, C. Bruns, A. Quaas, M. V. von Bergwelt-Baildon, H. Schlößer

Cancer immunology research, 2021

Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma

M. Garcia-Marquez, M. Thelen, S. Reinke, D. Keller, K. Wennhold, J. Lehmann, J. Veldman, S. Borchmann, A. Rosenwald, S. Sasse, A. Diepstra, P. Borchmann, A. Engert, W. Klapper, M. V. von Bergwelt-Baildon, P. Bröckelmann, H. Schlößer

Leukemia, 2021

T-cells of invasive candidiasis patients show patterns of T-cell-exhaustion suggesting checkpoint blockade as treatment option.

Sibylle C. Mellinghoff, M. Thelen, C. Bruns, M. Garcia-Marquez, P. Hartmann, Tatjana Lammertz, J. Lehmann, A. Nowag, J. Stemler, K. Wennhold, O. Cornely, M. V. von Bergwelt-Baildon, H. Schlößer

Journal of Infection, 2021

Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma

K. Leuchte, E. Staib, M. Thelen, Philipp Gödel, A. Lechner, Peter Zentis, M. Garcia-Marquez, D. Waldschmidt, R. Datta, Roger Wahba, Christian Wybranski, Thomas Zander, A. Quaas, U. Drebber, Dirk L. Stippel, Christiane J. Bruns, M. V. von Bergwelt-Baildon, K. Wennhold, H. A. Schlößer

Cancer Immunology and Immunotherapy, 2020

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies

H. Schlößer, M. Thelen, A. Lechner, K. Wennhold, M. Garcia-Marquez, S. Rothschild, E. Staib, T. Zander, D. Beutner, B. Gathof, Ramona Gilles, Engin Cukuroglu, Jonathan Göke, A. Shimabukuro-Vornhagen, U. Drebber, A. Quaas, C. Bruns, A. Hölscher, M. V. von Bergwelt-Baildon

Oncoimmunology, 2018